The sweetness of breast milk has proven to be as effective as a pain relieving strategy. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. On this page. There was high-quality evidence for the use of 2 mL 24% sucrose prior to venipuncture: PIPP during venipuncture WMD -2.79 (95% CI -3.76 to -1.83; I(2) = 0% (no heterogeneity; 2 groups in 1 study, n = 213); and intramuscular injections: PIPP during intramuscular injection WMD -1.05 (95% CI -1.98 to -0.12; I(2) = 0% (2 groups in 1 study, n = 232). 2: Haouari N, Wood C, Griffiths G, Levene M.. Comparison 32 Circumcision: sucrose (24%) versus EMLA, Outcome 5 Oxygen saturation (%) during circumcision. Comparison 23 Intramuscular injection (term infants): sucrose (20% to 25%) versus water or no intervention, Outcome 3 Duration of cry (s). Comparison 15 Heel lance: sucrose (24%) versus sucrose (24%) + swaddling, Outcome 2 Percentage increase in heart rate. NIH Comparison 33 Circumcision: sucrose (24%) versus EMLA + sucrose (24%), Outcome 2 N‐PASS score after 5 min. Comparison 37 Potentially painful procedures over seven days: sucrose (24%) versus water, Outcome 1 'Motor development and vigor' (MDV) domain of NAPI tool. Comparison 4 Heel lance: sucrose (24%) versus breastfeeding, Outcome 2 Comfort score. SweetUms is a 24% Sucrose Solution to help calm and soothe babies. Hypoglycemia is when the level of sugar (glucose) in the blood is too low. Babies 6 months and younger can have oral sucrose.  |  Results obtained for trials comparing oral sucrose and oral analgesics to placebo, and trials of environmental modification were either inconsistent or were not significantly different. Comparison 33 Circumcision: sucrose (24%) versus EMLA + sucrose (24%), Outcome 4 Respiratory rate (cycles/min). We identified high-quality evidence that sucrose reduces pain for heel lance, venipuncture and intramuscular injection. Comparison 14 Heel lance: sucrose (24%) versus sucrose (24%) + NNS, Outcome 2 Percentage increase in heart rate. Our objectives were to evaluate the effectiveness and safety of sucrose in newborns undergoing various medical procedures within 2 days of birth. Oral Sucrose Infants have a poorly functioning endogenous opioid system. Comparison 26 Bladder catheterization: sucrose (24%) versus sterile water, Outcome 1 Change in DAN score. Please enable it to take advantage of the complete set of features! doi: 10.1002/14651858.CD001069.pub3. The additional benefits of reducing pain during venepuncture when oral sucrose is combined with nonpharmacological strategies have not been extensively studied. Sucrose is effective for reducing procedural pain from single events such as heel lance, venipuncture and intramuscular injection in both preterm and term infants. Study protocol: parents as pain management in Swedish neonatal care - SWEpap, a multi-center randomized controlled trial. Stevens B, Yamada J, Ohlsson A. Sucrose analgesia in newborn infants undergoing painful procedures. Sucrose is considered a food product, and does not require a prescription. We assessed heterogeneity by the I(2) test. Comparison 22 Arterial puncture in preterm infants: sucrose (24%) versus no intervention, Outcome 2 Heart rate (beats/min) 1 min after procedure completed. Control interventions included no treatment, water, glucose, breast milk, breastfeeding, local anaesthetic, pacifier, positioning/containing or acupuncture. 2010 Jan 20;(1):CD001069. Comparison 11 Heel lance: sucrose (30% to 33%) versus glucose (30% to 33%), Outcome 1 Heart rate (beats/min) during heel lance. Comparison 9 Repeated heel lances: sucrose (20%) versus facilitated tucking, Outcome 1 Total Bernese Pain Scale for Neonates during heel lance. grimace) are present), or a combination of these and long-term neurodevelopmental outcomes. We assessed the risk of bias of included trials using the Cochrane 'Risk of bias' tool, and assessed the quality of the evidence using the GRADE system. The effects of sucrose on long-term neurodevelopmental outcomes are unknown. Comparison 21 Venipuncture: sucrose (24%) versus liposomal lidocaine, Outcome 3 Cry duration (s). Conditioning and hyperalgesia in newborns exposed to repeated heel lances. Background: Both groups of infants were given 1.0 mL of 25% sucrose solution 2 minutes before the vaccination, and 1 group additionally was given radiant warmth … Oral sucrose or other sweet-tasting solutions in small volumes, combined with non-nutritive sucking is effective to reduce pain in infants during minor procedures. Neonatal hypoglycemia affects as many as 5-15% of otherwise healthy newborns, and it can be associated with poor neurodevelopmental outcome if not promptly diagnosed and adequately treated.1,2Treatment choices vary depending on the gestational age of the infant, birthweight and risk factors for hypoglycemia. Sucrose as an analgesic agent for infants during immunization injections. In the first study infants drank 2 ml of water or 2 ml of a 0.17-0.34- or 0.51-M sucrose solution 1 min prior to blood collection. Comparison 16 Heel lance: sucrose (24%) versus sucrose (24%) + NNS + swaddling, Outcome 1 Revised NFCS. Secondary outcomes included separate physiological and behavioural pain indicators. Sweet-ease® for Infant Pain Relief Sweet-ease® is an oral liquid made of sugar (sucrose) and water that can be used to decrease pain in infants. Comparison 19 Venipuncture: sucrose (50%) versus water, Outcome 1 Duration of first cry (s). However, information on the commercial preparations not used at RHW might have been deleted. Comparison 23 Intramuscular injection (term infants): sucrose (20% to 25%) versus water or no intervention, Outcome 1 NIPS 1 min to 2 min after IM injection. Modest reduction of pain in newborns of both diabetic and nondiabetic mothers when sucrose was used for all medical procedures performed in the first 2 days after birth. Sucrose is widely used for the management of procedural pain in newborn infants, including capillary blood sampling, venepuncture and vascular cannulation. Selection criteria: To determine the efficacy, effect of dose, method of administration and safety of sucrose for relieving procedural pain in neonates as assessed by validated composite pain scores, physiological pain indicators (heart rate, respiratory rate, saturation of peripheral oxygen in the blood, transcutaneous oxygen and carbon dioxide (gas exchange measured across the skin - TcpO2, TcpCO2), near infrared spectroscopy (NIRS), electroencephalogram (EEG), or behavioural pain indicators (cry duration, proportion of time crying, proportion of time facial actions (e.g. Our objectives were to evaluate the effectiveness and safety of sucrose in newborns undergoing various medical procedures within 2 days of birth. Our objectives were to evaluate the effectiveness and safety of sucrose in newborns undergoing various medical procedures within 2 days of birth. The study was supported by Canadian Institutes of Health Research and SickKids Foundation . 2020 Sep 3;8:540. doi: 10.3389/fped.2020.00540. Comparison 5 Heel lance: sucrose (24%) + NNS versus water + NNS, or pacifier dipped in sucrose versus pacifier dipped in water, Outcome 3 PIPP 60 s after heel lance. Comparison 18 Venipuncture: sucrose (24% to 30%) versus control (sterile water or no treatment), Outcome 2 Duration of cry (s). This site needs JavaScript to work properly. How Is Sugar Water Prepared For Babies? Multiple randomised controlled trials have demonstrated that sweet-tasting solutions reduce … Comparison 15 Heel lance: sucrose (24%) versus sucrose (24%) + swaddling, Outcome 1 Revised NFCS. Sweet solutions, primarily sucrose or glucose, have been extensively shown over the past 2 decades to consistently reduce behavioral responses to acute procedural pain during single episodes of commonly performed painful procedures in newborn infants. Once weaned, toddlers … Arne Ohlsson ‐ ‐ is an author of the following included trial: Gibbins 2002. Cochrane Database Syst Rev. Sucrose Newborn Use Only 2017 NMF Consensus Group Sucrose Page 1 of 2 This RHW document is a modification of Neomed version. Boyd, S. (2002) Sucrose analgesia: A realistic alternative to conventional pharmacology for pain relief in neonates. Sucrose may be used for infants greater than 30 weeks and who are on full enteral feeds. Comparison 21 Venipuncture: sucrose (24%) versus liposomal lidocaine, Outcome 1 Facial grimacing score. Comparison 21 Venipuncture: sucrose (24%) versus liposomal lidocaine, Outcome 4 Heart rate (beats/min). For this trial two other authors (SH, AS) did the data abstraction and RoB assessments. 47 Yet from 2002 onward, 125 of the total 168 studies included in this review were published. Forest plot of comparison: 30 ROP examination: sucrose (24% to 33%) (sucrose or sucrose + NNS) versus control (water or water + NNS), outcome: 30.1 PIPP score during eye examination. Comparison 28 ROP examination: sucrose (24%) by syringe + swaddled + pacifier versus water by syringe + swaddled + pacifier, Outcome 5 Respiratory rate (breaths/min). The combination of sucrose and radiant warmth is an effective analgesic in newborns and reduces pain better than sucrose alone. Sucrose attenuates a negative electroencephalographic response to an aversive stimulus for newborns. Forest plot of comparison: 6 Heel lance: Sucrose (24%) + NNS vs. water + NNS, outcome: 6.2 PIPP 30 s after heel lance (term and preterm infants). The babies were randomly assigned to receive either 0.5mL of 24% of sucrose solution or an equivalent volume of sterile water on the tongue. Sucrose for analgesia in newborn infants undergoing painful procedures. Comparison 21 Venipuncture: sucrose (24%) versus liposomal lidocaine, Outcome 2 Observer‐rated pain (VAS) (cm). Comparison 28 ROP examination: sucrose (24%) by syringe + swaddled + pacifier versus water by syringe + swaddled + pacifier, Outcome 6 Oxygen saturation (%). Comparison 35 Circumcision: pacifier dipped in sucrose (24%) + DPNB versus pacifier dipped in water + DPNB, Outcome 1 Mean Behavioral Distress Scale scores during circumcision. doi: 10.1002/14651858.CD001069.pub4. When can Sweet-ease® be used? Sucrose may be used for infants greater than 30 weeks and who are on full enteral feeds. Journal of Neonatal Nursing 8(6): 184-90. Comparison 33 Circumcision: sucrose (24%) versus EMLA + sucrose (24%), Outcome 5 Oxygen saturation (%) during circumcision. Algopedol Sucrose 24% Solution can be used to help calm and comfort stressed babies when they are undergoing painful procedures including heel pricks and eye exams. Some features of the site may not work correctly. Comparison 16 Heel lance: sucrose (24%) versus sucrose (24%) + NNS + swaddling, Outcome 2 Percentage increase in heart rate. May be helpful for minor procedural pain. Comparison 32 Circumcision: sucrose (24%) versus EMLA, Outcome 3 Heart rate (beats/min) during circumcision. Multiple randomised controlled trials have demonstrated that sweet-tasting solutions reduce behavioural responses to acute painful stimuli. Presentation: 1. Administration of oral sucrose with or without NNS is the most frequently studied nonpharmacological intervention for procedural pain relief in neonates, but evidence has been insufficient to support that oral sucrose combined with NNS had a better effect on pain relief among NICU newborns than oral sucrose or NNS alone. Comparison 21 Venipuncture: sucrose (24%) versus liposomal lidocaine, Outcome 5 Oxygen saturation (%). Sucrose is effective for reducing procedural pain from single events such as heel lance, venipuncture and intramuscular injection in both preterm and term infants. Infants of diabetic mothers who…, Discover more papers related to the topics discussed in this paper, The Use of Oral Sucrose to Relieve Minor Procedural Pain in Neonates. Sugar has the potential to harm your baby’s gums or emerging teeth. Online ahead of print. 24% Oral Sucrose has been widely studied and proven to help reduce discomfort in infants. Prevention and management of pain in the neonate: an update. Cochrane Database Syst Rev. Comparison 2 Heel lance: sucrose (20% to 33%) versus water, Outcome 10 Respiratory rate (breaths/min) during heel lance. Comparison 2 Heel lance: sucrose (20% to 33%) versus water, Outcome 7 Total crying time. High-quality systematic reviews of sucrose for analgesia in newborn infants had already been conducted by 2001, 46 and recommendations from an international consensus statement on newborn pain treatment, also published in 2001, included using sucrose for painful procedures. 1 – 3 Sucrose has been widely recommended for routine use during painful procedures in newborn and young infants, 4 – 10 yet these recommendations have not been translated into … Data collection and analysis: We reported a mean difference (MD) or weighted MD (WMD) with 95% confidence intervals (CI) using the fixed-effect model for continuous outcome measures.  |  Authors' conclusions: 24% sucrose is not a medicine; it is another name for sugar water. Skin-to-skin care for procedural pain in neonates. So always check with your doctor first about a specific brand and kind of gripe water. The ready availability of this practical nonpharmacologic technique has the potential to reduce the burden of newborn pain. Johnston C. (2002) Routine Sucrose Analgesia During the First Week of Life in Neonates Younger than 31 Weeks Post-conceptional Age. It is believed that oral sucrose and other similar solutions affect endogenous opioid pathways, which are … Comparison 13 Heel lance (term infants): sucrose (24%) versus laser acupuncture, Outcome 2 Crying time (s). Sweet-ease® may be used if your baby is going to the operating room or having deep Sucrose is widely used to manage procedural pain in term newborns despite a lack of evidence of its effectiveness for different procedures and infant populations. Evidence from studies that could not be included in RevMan-analyses supported these findings. The researchers excluded babies from the study if they showed signs of tissue damage on the lower limbs, had previous surgery, serious illness or were born to diabetic mothers or opioid users. Sucrose 24% Solution How does this work? Stevens et al. Johnston C, Campbell-Yeo M, Disher T, Benoit B, Fernandes A, Streiner D, Inglis D, Zee R. Cochrane Database Syst Rev. 51 term babies, 4 days old (55 venepunctures) randomised to 2ml 24% sucrose, 2ml spring water, 1g EMLA or sucrose and EMLARCT (level 1b) Crying time/Heart rate/O2 saturation/Respiratory rate: Sucrose (compared with sterile water as placebo) significantly reduced crying time p=0.001 and heart rate p=0.04. Consistent Management of Repeated Procedural Pain With Sucrose in Preterm Neonates: Is It Effective and Safe for Repeated Use Over Time? Our objectives were to evaluate the effectiveness and safety of sucrose in newborns undergoing various medical procedures within 2 days of birth. Clipboard, Search History, and several other advanced features are temporarily unavailable. The registered nurse (RN) caring for your baby will decide if your baby is able to take the sucrose. Comparison 5 Heel lance: sucrose (24%) + NNS versus water + NNS, or pacifier dipped in sucrose versus pacifier dipped in water, Outcome 1 NFCS. The Cochrane database of systematic reviews, View 7 excerpts, cites background, results and methods, View 3 excerpts, references results and background, Archives of pediatrics & adolescent medicine, View 2 excerpts, references results and background, By clicking accept or continuing to use the site, you agree to the terms outlined in our, Using Sugar Water to Relieve Pain in Infants. Sarah Haliburton ‐ No conflict of interest to declare, Allyson Shorkey ‐ No conflict of interest to declare, Risk of bias graph: review authors' judgements about each risk of bias item presented…, Risk of bias summary: review authors' judgements about each risk of bias item for…, Forest plot of comparison: 6 Heel lance: Sucrose (24%) + NNS vs. water +…, Forest plot of comparison: 18 Venipuncture:…, Forest plot of comparison: 18 Venipuncture: sucrose (24% to 30%) versus control (sterile water…, Forest plot of comparison: 23 Intramuscular…, Forest plot of comparison: 23 Intramuscular injection (term infants): Sucrose (20‐25%) vs. water or…, Forest plot of comparison: 30 ROP examination: sucrose (24% to 33%) (sucrose or sucrose…, Comparison 1 Heel lance (term infants): sucrose (12% to 12.5%) versus water/routine care,…, Comparison 2 Heel lance: sucrose (20% to 33%) versus water, Outcome 1 PIPP…, Comparison 2 Heel lance: sucrose (20% to 33%) versus water, Outcome 2 PIPP…, Comparison 2 Heel lance: sucrose (20% to 33%) versus water, Outcome 3 PIPP…, Comparison 2 Heel lance: sucrose (20% to 33%) versus water, Outcome 4 DAN…, Comparison 2 Heel lance: sucrose (20% to 33%) versus water, Outcome 5 NIPS…, Comparison 2 Heel lance: sucrose (20% to 33%) versus water, Outcome 6 Duration…, Comparison 2 Heel lance: sucrose (20% to 33%) versus water, Outcome 7 Total…, Comparison 2 Heel lance: sucrose (20% to 33%) versus water, Outcome 8 Heart…, Comparison 2 Heel lance: sucrose (20% to 33%) versus water, Outcome 9 Percentage…, Comparison 2 Heel lance: sucrose (20% to 33%) versus water, Outcome 10 Respiratory…, Comparison 2 Heel lance: sucrose (20% to 33%) versus water, Outcome 11 Oxygen…, Comparison 2 Heel lance: sucrose (20% to 33%) versus water, Outcome 12 Skin…, Comparison 2 Heel lance: sucrose (20% to 33%) versus water, Outcome 13 Nociceptive‐specific…, Comparison 3 Heel lance: sucrose (50%) versus water, Outcome 1 Duration of first…, Comparison 3 Heel lance: sucrose (50%) versus water, Outcome 2 Percentage change in…. Why is sugar water used for babies? 4. Johnston C. (2002) Routine Sucrose Analgesia During the First Week of Life in Neonates Younger than 31 Weeks Post-conceptional Age. To determine the synergistic analgesic effect of sucrose and pacifiers. 24% sucrose is not a medicine; it is another name for sugar water. You are currently offline. Methods: We performed a double-blind, randomized controlled trial. Gripe water made with sucrose, while not dangerous, might not be the best choice either. There is some moderate-quality evidence that sucrose in combination with other non-pharmacological interventions such as non-nutritive sucking is more effective than sucrose alone, but more research of this and sucrose in combination with pharmacological interventions is needed. Comparison 31 Circumcision: sucrose 50% solution on a premature nipple containing a 2 x 2 cm sterile gauze pad moistened by the fluid versus no treatment, Outcome 1 Change from baseline in heart rate (beats/min). 2005 Jun;27(6):844-76. Comparison 32 Circumcision: sucrose (24%) versus EMLA, Outcome 4 Respiratory rate (cycles/min) during circumcision. Behavioral responses to sucrose provide an index of positive hedonic response in newborns. Most trials indicated some benefit of sucrose use but that the evidence for other painful procedures is of lower quality as it is based on few studies of small sample sizes. Check 24% sucrose pack is undamaged and within shelf life. It can cause problems such as shakiness, blue tint to the skin, and breathing and feeding problems. Journal of Neonatal Nursing 8(6): 184-90. Background: Sucrose is widely used to manage procedural pain in term newborns despite a lack of evidence of its effectiveness for different procedures and infant populations. Schmerz. [see RPA Newborn Care Pain policy] Sucrose may be used for infants greater than 30 weeks and who are on full enteral feeds. Comparison 2 Heel lance: sucrose (20% to 33%) versus water, Outcome 9 Percentage change in heart rate 1 min after heel lance. Comparison 2 Heel lance: sucrose (20% to 33%) versus water, Outcome 13 Nociceptive‐specific brain activity (mean weight). Besides, in some cultures, it is used as a traditional supplemental feeding along with breast milk. Comparison 30 ROP examination: sucrose (24% to 33%) (sucrose or sucrose + NNS) versus control (water or water + NNS), Outcome 1 PIPP score during eye examination. In 118 infants, the current study used repeated assessments to explore behavioral responses to sucrose solutions (24%/50% sucrose) compared to water across the first six months of infancy. The use of oral sucrose for procedural pain relief has been extensively studied in newborn infants. 2020 Dec 18. doi: 10.1007/s00482-020-00519-0. Cochrane Database Syst Rev. 2001;(4):CD001069. Fernandez M, Blass EM, Hernandez-Reif M, et al. Plus, you don’t want to get your baby used to being soothed with sweets. Comparison 7 Heel lance: sucrose (24%) + NNS+ NIDCAP support versus breast milk (by breastfeeding), Outcome 2 COMFORTneo score. Non pharmacological measures include ensuring, where possible, that the baby is calm, relaxed, warm, fed and that all necessary equipment for the procedure is at hand. Risk of bias summary: review authors' judgements about each risk of bias item for each included study. 3. Nonnutritive sucking and oral sucrose relieve neonatal pain during intramuscular injection of hepatitis vaccine. [Pediatric pain treatment and prevention for hospitalized children]. We performed electronic and manual literature searches in February 2016 for published randomised controlled trials (RCTs) in the Cochrane Central Register of Controlled Trials (CENTRAL; The Cochrane Library, Issue 1, 2016), MEDLINE (1950 to 2016), EMBASE (1980 to 2016), and CINAHL (1982 to 2016). Comparison 28 ROP examination: sucrose (24%) by syringe + swaddled + pacifier versus water by syringe + swaddled + pacifier, Outcome 1 PIPP during examination. Risk of bias graph: review authors' judgements about each risk of bias item presented as percentages across all included studies. Babies are usually given a dose of one-tenth of a gram of sucrose, a concentrated sugar solution, into their mouths before a procedure starts because doctors believe that it … Comparison 9 Repeated heel lances: sucrose (20%) versus facilitated tucking, Outcome 2 Total Bernese Pain Scale for Neonates during recovery. Comparison 27 Orogastric tube insertion in preterm infants: sucrose (24%) versus distilled water, Outcome 1 PIPP score intra procedure. Comparison 2 Heel lance: sucrose (20% to 33%) versus water, Outcome 11 Oxygen saturation (%) during heel lance. The analgesic effect of sucrose in full term infants: a randomized controlled trial. Presentation: 1. Objectives: Seventy-four studies enrolling 7049 infants were included. No other conflict of interest to declare. Oral Sucrose Associated With Decreased Discomfort During Newborn Screening. Comparison 23 Intramuscular injection (term infants): sucrose (20% to 25%) versus water or no intervention, Outcome 2 PIPP during IM injection (term infants). Bonnie Stevens ‐ is an author of the following included trials: Gibbins 2002; Johnston 1997; Mitchell 2004; Stevens 1999; Stevens 2005a. Comparison 18 Venipuncture: sucrose (24% to 30%) versus control (sterile water or no treatment), Outcome 1 PIPP score during venipuncture. Comparison 20 Venipuncture: sucrose (24% to 30%) versus sucrose (24% to 30%) + EMLA/Liposomal lidocaine cream on the skin, Outcome 3 DAN score during venipuncture. In a randomized and controlled trial, 34 newborns were administered 2 mL of water or sucrose solution before the heelstroke. Fernandez M(1), Blass EM, Hernandez-Reif M, Field T, Diego M, Sanders C. Author information: (1)Department of Pediatrics, University of Miami School of Medicine, Miami, FL 33101, USA. Comparison 35 Circumcision: pacifier dipped in sucrose (24%) + DPNB versus pacifier dipped in water + DPNB, Outcome 2 Mean plasma cortisol levels n mol/dL. Comparison 28 ROP examination: sucrose (24%) by syringe + swaddled + pacifier versus water by syringe + swaddled + pacifier, Outcome 3 Heart rate (beats/min). Further investigation of repeated administration of sucrose in neonates is needed. Cochrane Database Syst Rev. newborn infants during painful blood tests and injections. Sucrose is widely used for the management of procedural pain in newborn infants, including capillary blood sampling, venepuncture and vascular cannulation. Check the sucrose prescription, as per network guideline.. Ascertain whether sucrose is to be given with a pacifier. Comparison 3 Heel lance: sucrose (50%) versus water, Outcome 2 Percentage change in heart rate 1 min after heel lance. Sugar has the potential to harm your baby’s gums or emerging teeth. Giving infants a 24% sucrose solution and exposing them to radiant warmth shortly before vaccination led to a 50% reduction in time the newborns spent crying and grimacing after the inoculation. Semantic Scholar is a free, AI-powered research tool for scientific literature, based at the Allen Institute for AI. Nutrients. Comparison 13 Heel lance (term infants): sucrose (24%) versus laser acupuncture, Outcome 1 NIPS score. If your baby is in constant pain or is colicky, then consult a doctor, who can … Comparison 2 Heel lance: sucrose (20% to 33%) versus water, Outcome 6 Duration of first cry (s). Comparison 32 Circumcision: sucrose (24%) versus EMLA, Outcome 2 N‐PASS score after 5…, Comparison 32 Circumcision: sucrose (24%) versus EMLA, Outcome 3 Heart rate (beats/min) during…, Comparison 32 Circumcision: sucrose (24%) versus EMLA, Outcome 4 Respiratory rate (cycles/min) during…, Comparison 32 Circumcision: sucrose (24%) versus EMLA, Outcome 5 Oxygen saturation (%) during…, Comparison 33 Circumcision: sucrose (24%)…, Comparison 33 Circumcision: sucrose (24%) versus EMLA + sucrose (24%), Outcome 1 N‐PASS…, Comparison 33 Circumcision: sucrose (24%) versus EMLA + sucrose (24%), Outcome 2 N‐PASS…, Comparison 33 Circumcision: sucrose (24%) versus EMLA + sucrose (24%), Outcome 3 Heart…, Comparison 33 Circumcision: sucrose (24%) versus EMLA + sucrose (24%), Outcome 4 Respiratory…, Comparison 33 Circumcision: sucrose (24%) versus EMLA + sucrose (24%), Outcome 5 Oxygen…, Comparison 34 Circumcision: sucrose solution…, Comparison 34 Circumcision: sucrose solution (50%) on a premature nipple containing a 2…, Comparison 35 Circumcision: pacifier dipped…, Comparison 35 Circumcision: pacifier dipped in sucrose (24%) + DPNB versus pacifier dipped…, Comparison 36 Echocardiography (term and…, Comparison 36 Echocardiography (term and preterm infants): sucrose (24%) versus no medication/placebo, Outcome…, Comparison 37 Potentially painful procedures…, Comparison 37 Potentially painful procedures over seven days: sucrose (24%) versus water, Outcome…, NLM Comparison 20 Venipuncture: sucrose (24% to 30%) versus sucrose (24% to 30%) + EMLA/Liposomal lidocaine cream on the skin, Outcome 2 PIPP score during recovery period. Healthy newborns and infants are generally able to drink sufficient amounts of breastmilk or formula to remain hydrated. Many centres around the world routinely give a few drops of sucrose solution in to the baby’s mouth a couple of minutes before the painful procedure. 2013 Jan 31;(1):CD001069. Are any conditions that might prevent your baby used to being soothed with sweets non-pharmacological intervention for procedural management... Registered nurse ( RN ) caring for your baby ’ s gums or teeth... And vascular cannulation and RoB assessments 12 ; 20 ( 1 ): sucrose ( 24 )! Term infants: sucrose ( 50 % ) versus distilled water, Outcome 1 Revised NFCS score circumcision! Versus EMLA, Outcome 1 Facial grimacing score baby-friendly hospital initiative medicine ; it is in! Reduce behavioural responses to sucrose provide an index of positive hedonic response in newborns undergoing various procedures... Appropriate above 3kg 33 % ) versus water, Outcome 2 Observer‐rated pain VAS. 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